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42 To test for altered autophagy, especially of mitochondria, a previously determined metabolite target, 25 we utilized a combination of molecular and phenotypic assays

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BMC Biophys

Bethesda (MD): National Library of Medicine (US)

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In addition to its synergistic effects with TNF, IL-17 suppresses melanogenesis through ROS-dependent autophagic melanocyte apoptosis and stimulates keratinocytes to secrete IL-1 through the nuclear factor-B (NF-B)/ROS/ NLR Family Pyrin Domain Containing 3 (NLRP3)/caspase 1 pathway 152