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Holsen et al., 2008

However, this procedure may be more beneficial for some groups of people, and for some, it may even be life-saving

Through its lipid A component, which acts as a classic pathogen-associated molecular pattern (PAMP), LPS activates Toll-like receptor 4 (TLR4) signaling on immune and other cells, triggering the release of pro-inflammatory cytokines such as IL-1 and TNF-, thereby establishing a direct mechanistic link between gut barrier integrity, innate immune activation, and systemic inflammation in gout (Lu et al., 2008)

Intriguingly, melatonin supplementation improves oxidative DNA capacity (measured as urinary excretion of 8-OHdG) in NS workers, suggestive of a possible preventive intervention 30

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