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The transition to the premalignant state is driven by the extent of CDKN2A/B deficiency [38]
First, hepatocyte lipid overload and the presence of fat metabolites have been shown to activate serine kinase cascades that cause insulin resistance (62, 232235)
Bioact Mater 4:380386
10.1038/s41591-018-0128-1 82 Robinson-CohenC.NewittR.ShenD
Dietary NAD + could partially resolve SARS-CoV-2-induced dysregulated gene expression and mitochondrial metabolism 523
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