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Role of insulin-like growth factor binding protein-4 in prevention of colon cancer

[DOI] [PubMed] [Google Scholar] 542

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

39 , 40 , 41 However, the molecules are still susceptible to the rapid clearance from the synovial cavity and reduced tissular penetration

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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices 100 days, and significantly increased the median event-free survival relative to L-PAM alone