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The oxidation of the dithiol groups of Trx(SH) 2 consequently results in the formation of intra-chain disulfide bridges and hence the oxidized form of Trx proteins (TrxS 2 )

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Interestingly, neurodegeneration and disease pathways, such as AD and Parkinsons disease, glutamatergic synapse, energy metabolism, or amino acids metabolism pathways were also prominently identified (Fig

We observe that all the GluK3 N-glycan mutants recovered from glutamate-evoked desensitized state faster than the wild type receptors with a rec of 0.5 s (Asn 247) (unpaired t-test, P = 0.0870)

Another factor, connecting the intestine to brain pathways, is severe stress