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33 Non-specific cysteine transporters While influx transporters are the main means by which cells acquire cystine, cysteine can also be taken up from the extracellular milieu into cells directly by excitatory amino acid transporter 3 (EAAT3) and the alanine-serine cysteine transporters 1 and 2 (ASCT1/2), all of which are known to be overexpressed in different cancer types 34 (Table 1)

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A follow-up study investigated the distribution of WDR49-positive astrocytes in other subtypes of FTD and in AD, and showed that WDR49-positive astrocytes are most abundant in FTD-GRN, have a different morphology in FTD with TDP43 versus TAU pathology, and colocalize with senile plaques in AD 226