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This work was funded by NIH/NIA grant R00 AG050777 and Seed Funds from the Cleveland Clinic Lerner Research Institute to C.H

Therefore, it is metabolized via either transmethylation or transsulfuration reactions (Figure 3)

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Physiol Rev 1929;IX:399431

doi: 10.1089/ars.2015.6615 83 HuangCZhangCYangPChaoRYueZLiCet al

Some kinase type I inhibitors such as sunitinib have been shown to activate IRE1 RNase activity by promoting oligomerization of this enzyme (Feldman et al
