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Key microbiota and metabolites were predominantly enriched in pathways such as amino acid metabolism, lipid metabolism, and nucleotide metabolism

Applying type I PRMT inhibitor GSK3368715 can inhibit PRMTS-mediated epigenetic modification of IFN genes, increase the response of IFN genes to immune signals, and reduce the expression of VEGF in immunosuppressive cells

ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14

Metabolite concentration was normalized to the protein concentration in lysates

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(2001) ve Wang et al., 2023, Klatka et al., 2023)