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Tretinoin risks and side effects While generally safe for most people, tretinoin cream can cause side effects especially when you first start using it: Increased sensitivity to the sun Skin irritation, redness, dryness, or peeling Temporary acne flare-ups Speaking from experience, the saying, It gets worse before it gets better, definitely applies to tretinoin so be prepared

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GHK further inhibited TGF-1, p-Smad2, p-Smad3, and IGF-1 expression, indicating its potential as a subject of further research in pulmonary fibrosis by targeting the TGF-1/Smad 2/3 and IGF-1 pathways