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For example this drug displays a much higher affinity for GSTM2-2 than for GSTP1-1 98

The result indicates that the overall pathway is feasible but acetate kinase (AckA) is the limiting step (Figure 4)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Naber TH, Baadenhuysen H, Jansen JB, Van Den Hamer CJ, Van Den Broek W

The Keap1Nrf2 pathway, an essential regulator of oxidative stress, has been recently discovered to participate in protecting cells against ferroptosis 10