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Treatment of the consequences of addiction to NSAIDs Concept of NSAIDs NSAIDs are nonsteroidal anti-inflammatory drugs, which are the most commonly used agents in pain relief

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miRNAs are known for their ability to modulate gene expression through target mRNA binding to control protein production or mRNA breakdown

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Apart from ibuprofen, the action of CYP2C9 on other target NSAIDs has been reported wherein diclofenac is metabolized to 4-hydroxydiclofenac, flurbiprofen is metabolized to 4-hydroxiflurbiprofen and naproxen is metabolized to 6-desmethylnaproxen [35]

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