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Furthermore, RNA sequencing analysis demonstrated significant alterations in cognitive-related signaling pathways in both lung and hippocampal tissues following PS-MPs exposure, particularly affecting the expression of factors associated with neuroplasticity

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Given the structural and functional similarities between CNS and ENS neurons, it is likely that energy failure similarly contributes to enteric neurodegeneration

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The exosomal membrane is characterized by a lipid bilayer architecture, enriched with cholesterol, sphingomyelin, ceramide, and diglycerides (44)

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