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In the resorbable blast material method, the excessive use of acids for particle debris removal is no longer necessary as it does not penetrate deep into the titanium surface while still delivering homogenous micro and macro porosity for the optimal implant surface topography both at cellular and protein levels

Higher concentrations allow smaller injection volumes but may increase injection site discomfort

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Bacteria and fungi are also reported to produces organic acids as a natural chelating agent for HMs (Seneviratne et al., 2017)

Alternatively, bacteria may encounter microenvironments with restrictive conditions (nutritional deprivation, physical and chemical stress, etc.) that favor the development of phenotypic traits that increase the bacterial recalcitrance to the antibiotic (e.g., slow to no growth, reduced metabolism, increased stress responses, etc.) (Peyrusson et al., 2020
