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Apart from these two types of FINs, other methods or compounds can also induce ferroptosis (Figure 1): L-buthionine sulfoximine (BSO) suppresses glutamate-cycteine ligase (GCL) and induces GSH depletion (Seiler et al., 2008

Arginase-fc demonstrates arginine depletion activity equivalent to native arginase

In an updated systematic review of randomized trials for the prevention of cisplatin-induced ototoxicity, an international, multidisciplinary panel of experts and patient advocates established several clinical practice guidelines (44): (1) The panel made a strong recommendation for administration of systemic sodium thiosulfate in nonmetastatic hepatoblastoma, a weak recommendation for administration in other nonmetastatic cancers, and a weak recommendation against its routine use in metastatic cancers

This first step is catalyzed by ATP sulfurylase

Together, they address both the structural repair needs and the inflammatory environment that often impedes healing

A variety of nutrients are involved in the closure of the neural tube