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More serious but rare adverse events include pancreatitis, gallbladder problems, and changes in kidney function

Some studies have suggested that statins may upregulate toll-like receptors on activated dendritic cells, enhance the secretion of proinflammatory cytokines, and could be related to the development of autoimmune hepatitis

Edinburgh Hospital Reports: The Supervision of the Editorial Committee of the Royal Infirmary Royal Hospital for Sick Children

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Barouk S, et al

Commentary on comparison of a fractional microplasma radiofrequency technology and carbon dioxide fractional laser for the treatment of atrophic acne scars: a randomized split-face clinical study

Low urinary pH predisposes for uric acid precipitation since the pKa of uric acid is 5.7, therefore the solubility of uric acid decreases with low pH, and thus increasing the risk of kidney stones (8, 44)