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The lumbar region of the spinal cord (segments L4L5), dorsal root ganglia (DRGs), and sciatic nerve were dissected for molecular and biochemical analyses
MOTS-C is a mitochondrial-derived peptide encoded within mitochondrial DNA

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In the pathological environment of PAH, aberrant expression of histone-modifying enzymes is closely associated with disease progression

To a large extent, this tolerance development can be compensated for by gradually titrating the medication dose upwards, usually by adding a second dose in the early afternoon to provide reasonable all-day appetite control
