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Another study also demonstrated that psilocin increases brain-derived neurotrophic factor (BDNF) levels mediated by the serotonin 2 A receptor, further enhancing plasticity in human cortical neurons [26]

2020 Dec 1 [cited 2023 Aug 21];6(1):15

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Interleukin 6: at the interface of human health and disease

This can lead to a cycle where poor sleep lowers your antioxidant defenses, and those lowered defenses further disrupt your ability to rest