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The pathophysiology of bone demineralization is different in GSD XI, where patients are more prone to develop hypocalcemia and hypercalciuria, hyperphosphaturia with or without hypophosphatemic rickets in early childhood, osteoporosis and osteomalacia [23, 24, 91,92,93,94]

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R.ShulmanG

Regarding adrenal steroidogenesis inhibitors, ketoconazole exerts cholesterol-lowering effects by inhibiting adrenal steroid synthesis and hepatic cholesterol production, historically serving as a therapeutic option for familial hypercholesterolemia before the advent of statins [292, 293]

Molecules 25 , 5774 (2020)
