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doi: 10.1016/j.arcmed.2016.07.003 225 Samsami-korMDaryaniNEAslPRHekmatdoostA

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Many people mistakenly attribute these reactions to the active ingredient when the problem lies with inactive components in the formula

These studies primarily rely on preclinical (animal) data and limited early-stage human pilot studies

In the event that this observation is corroborated in human subjects, a TRPC4 antagonist could potentially exhibit clinical efficacy in the treatment of addiction (Koivisto et al., 2022)

Intraneuronal amyloid oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo
