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They also lack the physiological context of an intact organism, limiting their utility for evaluating therapeutic strategies that depend on systemic immune interactions, tissue trafficking, or in vivo immune-cell generation and remodeling
Nucleic acids contain a sugar-phosphate link in their backbone

Curr Opin Plant Biol 63:102048 Graziano M, Lamattina L (2007) Nitric oxide accumulation is required for molecular and physiological responses to iron deficiency in tomato roots
The primary gastric adenocarcinoma cell line ACP02 was developed and established by the Human Cytogenetics Laboratory, Federal University of Par (UFPA) ( mycoplasma testing was conducted to confirm the absence of contamination

Given that increased levels of 4-HNE and/or MDA have been associated with various forms of ocular pathologies (including cataracts) [144-146], the enzymatic detoxification of these reactive aldehydes represents yet another mechanism by which ALDH3A1 and ALDH1A1 protect ocular tissues against UV radiation-induced damage

doi: 10.3177/jnsv.46.141