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Finally, alterations in iron metabolism could help in the study many metabolic pathologies related to iron metabolism, from uptake to release, allowing the development of increasingly new personalized drugs for specific molecular mutations, limiting the incidence of some pathologies that are still considered as health emergencies

In addition, a study identified a positive feedback bistable ERN2-XBP1S pathway upregulated MUC5B mRNAs in IPF and further regulated mucus secretion, providing an unfolded protein response (UPR)-dependent mechanism with rs35705950 variant ( Environmental Environmental exposure and genetic predisposition may have a synergistic effect in the development of IPF (Figure 1)