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Abuse of and addiction to opioids in some individuals may not be accompanied by concurrent tolerance and symptoms of physical dependence

Gentile MT, Camerino I, Ciarmiello L, Woodrow P, Muscariello L, De Chiara I, et al

Taking Linzess immediately after a meal, especially a high-fat meal, can lead to diarrhea (loose stools and a higher stool frequency) as well as other gastrointestinal side effects such as gas, bloating, and stomach pain

10.1038/s41418-021-00814-y 123 MousaR

Activated T cells that have undergone differentiation to carry out specific activities, such as cytotoxicity or cytokine production, are known as effector T cells (78)