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When citrulline is co-delivered intravenously with arginine, the result is a smoother pharmacodynamic curve, mitigating rapid peaks and troughs in vascular tone that otherwise accompany arginine-only infusions

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In situations when the emergency provider is not X-waivered and next day follow-up cannot be guaranteed, the patient can be directed to return to the ED for subsequent doses of buprenorphine (up to 72 hours after initial presentation) until outpatient follow-up and long term MOUD can be established