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Description
The therapeutic window for selenium is limited, and long-term consumption of more than 400 g/day can cause selenosis, which manifests as gastrointestinal issues, brittle nails and hair, dermatological changes, and infrequently, neurological problems [19]

[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Oh C.K., Ahmed M.S.F., Xie C., Ryu J.H., Choi J., Chung J.S., Roh G.S., Kim H.J., Cho G.J., Choi W.S., Kang S.S., Lee D.H

Nootropic effects

Younes A, Consoli U, Snell V, Clodi K, Kliche KO, Palmer JL, Gruss HJ, Armitage R, Thomas EK, Cabanillas F, Andreeff M

In line with this, a ROS/RNS-dependent regulation of IL-6 was envisaged in response to muscle exercise as shown by an impaired release of this cytokine after administration of vitamins A, C and E or inactivation of NOS by N()-nitro-l-arginine methyl ester (L-NAME) [110,111]

The mitochondrial AST enzyme is encoded by the GOT2 gene which is located on chromosome 16q21 and is composed of 10 exons that generate two alternatively spliced mRNAs encoding precursor proteins of 430 amino acids (isoform 1) and 387 amino acids (isoform 2)
