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167,171,172 Management strategies focus on tight glycemic control to prevent further nerve damage, symptomatic treatment with analgesics for pain management, physical therapy to maintain muscle strength and prevent contractures, and surgical interventions for entrapment neuropathies when necessary

Ayanwuyi et al., 2013) have indicated a strong genetic influence on the role of CRF in mediating stress responsiveness as well as alcohol drinking and risk for dependence