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Studies in animal models and humans have shown that environmental AD risk factors, such as diet, lifestyle, alcohol, smoking and pollutants, can induce epigenetic modifications of key AD-related genes and pathways

42 AKT directly and indirectlyby the activation of mTOR, which promotes the stabilization of the transcription factor hypoxia-inducible factor-1stimulates the expression of glucose transporters and key glycolytic enzymes (Figure 3)

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