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NPR1 containing several conserved Cys residues controls the expression of over 2,200 defense response genes in Arabidopsis and has stable structure that forms a high molecular weight (HMW) oligomer, which makes the protein confine at the plant cytoplasm (Mou et al., 2003

Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin

He also pointed out that should this happen, they would have no one to blame except themselves (13:9)

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Dynamic pressure-flow relationships of brain blood flow in the monkey