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Prostate cancer is the fourth most common cancer in adults, and it is estimated that approximately 40% of patients with localized disease will undergo radical prostatectomy

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Studies have indicated that the increase of the autophagy level in vivo can lead to the degradation of ferritin and the increase of iron level, thus leading to oxidative damage of cells through the Fenton reaction [66, 67]

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Interestingly, increased GSTP1 expression has been shown to maintain the CSC phenotype in lung adenocarcinoma and facilitated metastasis through regulating EMT (Wang et al