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591 Additionally, another Keap1-Nrf2 PPI inhibitor 74 , which combined conformational features significantly similar to the Keap1-Nrf2 ETGE complex, revealed the unique inhibition mechanism and provided an innovative strategy for the development of new Keap1-Nrf2 PPI inhibitors

Nanoscale drug delivery systems for cancer therapy using paclitaxelA review of challenges and latest progressions

DNA Cell Biol 32(3):98103 Vervoort LMT, Ronden JE, Thijssen HHW (1997) The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation

doi: 10.1038/s41598-017-15510-6 67

Thus, we propose that these structural rearrangements are due to the positioning of the hydrogen bond, which could affect the flexibility of nearby loops, and possibly trigger the movement of the Cys190-containing loop ( Figure 7D )

Effects of microsomal enzyme induction on paracetamol metabolism in man