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The World Health Organization (WHO) recommends that all people 50 and older who live in a country where shingles is a concern, such as the United States, get the shingles vaccine, even if they: Had shingles in the past (its possible to get shingles more than once) Received the old live zoster vaccine (Zostavax), which the recombinant zoster vaccine (Shingrix) replaced The WHO also recommends that adults (18 and older) get the shingles vaccine if they have a weakened immune system either from a condition like cancer or HIV or from certain medications that make them more vulnerable to shingles

Implications of CAC in Cancer To date, the correlation between CAC and cancer has received little attention, and only a few studies have reported a link between the altered expression of CAC and cancer (Table 1)

Activated pancreatic stellate cell (PSC), the main stromal cell of PDAC, accounts for 50% of the stroma and is comprehensively implicated in PDAC metabolic imbalances, including reprogramming of stroma and energy metabolism 9