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Widespread of horizontal gene transfer in the human genome

Among cataract-associated CRYAB mutations, the D140N variant results in an altered tertiary structure, increased surface hydrophobicity, and increased heat-induced aggregation, with a dominant negative effect on its wild-type counterpart

doi: 10.1113/jphysiol.1995.sp020960

Pharmacodynamic studies confirmed the enhanced anticancer potential of the SLN formulations without any hepatic or renal toxicity (Khatri et al., 2020)

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