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68 Of note, the BNIP3/NIX pathway was specifically up-regulated when mitochondrial oxidative stress was generated in the hypoxic environment to further induce mitophagy

Premature oxidation would limit its effectiveness
10.1038/gt.2015.32 82 ThomopoulosS.DasR.Sakiyama-ElbertS.SilvaM
Intratumoral immunization: a new paradigm for cancer therapy
