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and pro-inflammatory cytokines, including IL-1 and IL-6, pro-inflammatory transcription factor nuclear kappa B (NF-B), pro-fibrotic proteins transforming growth factor- (TGF-), and renal antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA)]

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Clinicians should prefer lower concentrations and consider alternatives or formulations with mitigated toxicity for sensitive applications like eye drops

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