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In some embodiments, the otoprotectant is a compound of Formula (IX) having the structure of Formula (IXa): In some embodiments, the otoprotectant is a compound of Formula (X): wherein: X is a single bond, double bond, CH 2 , or O

or Have had optimal treatment with allopurinol, however, renal impairment means that probenecid cannot be added or is likely to be ineffective Patients who have had previous Special Authority approval for benzbromarone are also eligible for Special Authority approval for febuxostat (see: Benzbromarone to be discontinued)

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