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Indeed, Genestier and colleagues have reported that methotrexate diminishes antigen-stimulated T-cell proliferation both in vitro and in T cells taken from patients taking methotrexate [24]

Whitney K, Nikulina E, Rahman SN, Alexis A, Bergold PJ

Carboni JM, Wittman M, Yang Z, Lee F, Greer A, Hurlburt W, et al

Combined with the metabolic changes triggered by dual GIP and GLP-1 receptor activation, tiredness during the first several weeks is expected

26 Three out of the five RCTs reviewed in this meta-analysis showed improvements in at least one cognitive function outcome measure, and pooled data from three trials showed a significant improvement in working memory, whilst improvements in processing speed failed to reach statistical significance

Mao et al