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When norepinephrine is released in response to cold sensation it binds to -adrenergic receptors on the surface of brown adipocytes triggering the activation of adenylate cyclase

10.1128/CMR.00014-09 Clin Microbiol Rev

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doi: 10.1186/s13075-017-1418-6
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Although focused on the eye, these findings reflect broader CNS protection and raise the possibility that early intervention with Epitalon may buffer against age-related sensory decline
