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What the evidence actually supports: Preclinical efficacy and reasonable safety at tested doses

[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Mottillo EP, Zhang H, Yang A, Zhou L, Granneman JG

For instance, many people note a quick boost in energy levels shortly after receiving a B12 injection

This interaction was mapped at the hydrophobic domain of G0S2 and the patatin-like domain of PNPLA2, whereby overexpression of G0S2 diminished adipocyte lipolysis, and deletion increased both basal and stimulated lipolysis (52)

A deficiency in B12 can lead to megaloblastic anemia, characterized by larger-than-normal red blood cells that may not function properly