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Abstract Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical challenge, with oxidative stress as a key driver

Additionally, methylated quinolines such as 5-amino-1-methylquinolinium have been identified as NNMT inhibitors through ligand-based in silico methods and biological evaluations 203

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The AT mechanism of all of the above-mentioned compounds usually involves conversion of manganese to an Mn IV -oxo form, which is then reducible by endogenous or exogenous AT (e.g., glutathione or vitamin C) activity (Halliwell and Gutteridge, 2015)

4.5 Metal-organic frameworks The investigators have found that enzyme-integrated metal-organic frameworks (MOFs) had antioxidant activity and chiral-dependent BBB trans endocytosis