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Description
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

JCI Insight 4(24):e132975

This creates a multi-layered defense network

Rbm4 dictates escc cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting lkb1-ampk-axis
Malateaspartate shuttle A biochemical system in which malate carries reducing equivalents generated in the cytoplasm in the form of NADH across the inner membrane of the mitochondrion which is impermeable to NADH for oxidative phosphorylation
Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G