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In brain OHB can be produced in astrocytes from oxidation of fatty acids or catabolism of amino acids and is metabolised in the mitochondria of all brain cell types although uptake across the blood brain barrier is a metabolic control point

In this Review, the authors consider the nomenclature, pathophysiology, clinical presentation and management of these functional gastroduodenal disorders, with a particular focus on cyclic vomiting syndrome.

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