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This is because lots of supplements contain metals like zinc, copper, and chromium, which have been known to cause this unpleasant side effect, according to Cleveland Clinic
Malar J 9: 338
NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension
To understand why this happens, we have to go to the synaptic cleft, or the connection between neurons
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