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Macfarlane, G

Long-term and Low-dose Exposure Studies: Future research should focus on chronic exposure at environmentally relevant doses to better mimic real-life human exposure conditions

doi: 10.1016/j.tibs.2003.11.007 48

Extended use isnt well-studied in humans, so most experts recommend cycling it, typically 48 weeks on, followed by a few weeks off, to support safety and effectiveness.

The infusions are expensive, often running $300$800 or more per session, and achieving meaningful results typically requires multiple sessions

This deserves a closer discussion when Not every sore arm or brief wave of nausea signals a problem
