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There has been a tremendous interest from the pharmaceutical industry in developing selective and potent inhibitors of these enzymes

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Small differences in preparation can lead to noticeably different outcomeseven at identical concentrations

Adaptations in Ion Channels CNS neurons express a wide range of calcium- or voltage-gated potassium (K + ) and calcium (Ca 2+ ) ion channels
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The development of targeting strategies is highly required to reduce the side effects from therapy and prolong the median survival of the patients
