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Clinical stages of Alzheimer's disease Because of the complexity of Alzheimer's brain changes, as well as the changes in cognitive and physical abilities that follow, the Alzheimer's Association formed a workgroup to revise the diagnostic criteria for Alzheimer's disease with the end goals of facilitating consistency in how Alzheimer's is diagnosed and described and incorporating the latest evidencebased information

Thermal sensitivity testing demonstrated that as a group, at baseline, the subjects exhibited a reduction of function of cold detection threshold of all three regions tested, and reduced function in warm detection threshold in the foot and hand (Figure 7)

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