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104 Tryptophan and its derivative, 5-hydroxytryptophan (5-HTP), have been used to treat depression, anxiety, and sleep disorders, 103,105 and higher dietary tryptophan intake was linked to lower risk of depression and increased self-reported sleep duration in an observational study with 29,687 participants

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Intriguingly, modification of chromatin enabled by utilizing these metabolites alters the expression of genes involved in regulating lipid metabolism