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In addition, patient stratification is taking further shape with active research groups developing more reliable epigenetic mapping and multiplex biomarker panel approaches to substantiate biological endophenotypes such as BDNF hypermethylation that serve as biological hieroglyphics for cognitive decline or mood disorders

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Patients with CeD frequently exhibit low folate concentrations due to persistent enteropathy, inadequate adherence to a gluten-free diet or consumption of non-fortified gluten-free products

Overall, existing clinical treatment methods primarily focus on symptom control and do not intervene in the fundamental pathological mechanisms of disc degeneration

Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice

The tumor microenvironment (TME) includes surrounding cells such as epithelial cells, cancer-associated fibroblasts (CAFs), endothelial cells (ECs), pericytes, and immune cells