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In extension of that work it was only recently demonstrated that 87% of VH proteins were also detected in AH (Wolf et al., 2023)

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This modulation effectively inhibits the release of inflammatory mediators and helps to maintain the balance of the local immune microenvironment (Wang L

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This indicates the existence of a GGCT-mediated Gln metabolic shunt in tumor cells: Gln is prioritized for conversion to GSH, which scavenges ROS, alleviates oxidative stress, and ultimately promotes tumor cell proliferation