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Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

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Increasing evidence has demonstrated that in response to hypoxia, tubular epithelial cells undergo changes and function as inflammatory and fibrogenic cells (they may undergo tubular epithelial cell death/atrophy, maladaptive repair, metabolism switch, senescence, etc.), with the consequent production of various bioactive molecules that drive interstitial inflammation and fibrosis

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Jama 323 , 11751183 (2020)