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Description
Its mechanism is competitive inhibition within the NNMT catalytic pocket, blocking the methyl transfer from SAM to nicotinamide
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5-amino-1MQ showed concentration-dependent inhibition of NNMT in fully differentiated adipocytes that could be fit to a 3-parameter sigmoidal dose-response curve with a calculated EC 50 = 2.3 +/ 1.1 M (Figures 2E, 2F
Slowly push the plunger upwards to remove the air from the syringe
Ng, Journal (Endocrinology, Volume 142, Issue 12, December 2001, Pages 51825189)
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