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This result resembles what it was found in recent reports documented that ceramide accumulation compromises mitochondria respiration in the cerebral cortex (Carr et al., 2023) (Figure 2)

Beta blockers, which include propranolol, timolol, and metoprolol, are designed to block -adrenoceptors that reside on cerebral blood vessels

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Conflicts of Interest: The authors declare that they have no conflicts of interest to report regarding the present study

Thus, inhibition of the MVA pathway may lead to ferroptosis, thereby validating the crucial role of GPX4 activity in preventing ferroptosis